C14-CHOLESTEROL

Mechanism of cholesterol absorption. II. Changes in free and esterified cholesterol pools of mucosa after feeding cholesterol-4-C14.

In a previous study (1) it was shown that the transfer of fed cholesterol-4-Cl4 to the lymph was very rapid; the peak of absorption occurred in 6 to 8 hours, but cholesterol-4-Cl4 continued to appear in lymph up to 48 hours. There was considerable endogenous dilution of the fed cholesterol-4-Cl4 during its passage from the lumen to the lymph; this dilution was smallest during the period of rapi...

In vivo incorporation of acetate-1-C14 into cholesterol and fatty acids following testosterone propionate administration.

• With the development of a wide variety of hypocholesterolemie agents, the hypercholesterolemia commonly associated with coronary and aortic atherosclerosis has assumed a position of paramount importance in the quest for some reliable means of preventing atherosclerosis. Though hypercholesterolemia in itself has not been indicated as the primary cause of atherosclerosis, indications are that i...

Metabolism of Coprostanol-c14 and Cholestanol-4-c14 in Man.

Biogenesis of estrogens by the human ovary. III. Conversion of cholesterol-4-C14 to estrone.

Although cholesterol has been accepted as a precursor of the neutral steroid hormones, its role in estrogen formation has been subject to much doubt. It was postulated, on the basis of experiments in z&o in the pregnant mare, that cholesterol was not an estrogen precursor (1). The test animal had readily converted radioactive acetate to labeled estrogens, but had failed to convert administered ...

Metabolism of cholesterol-4-C14 in bile duct cannulated chicks and rats.

THE main pathway of cholesterol catabolism involves the conversion of cholesterol to bile acids which are eliminated via the bile and feces. As liver cholesterol is considered to exist in equilibrium with serum cholesterol, nutritional factors accelerating cholesterol catabolism may lower the serum cholesterol level. Furthermore, it is well known that hypercholesterolemia and subsequent experim...